ACTH-Producing Tumors (Cushing's disease) Standard Treatment Surgery, radiation therapy , a combination of both or Mitotane or Ketoconozol plus radiation. Investigational • Heavy-particle radiation. Prolactin-Producing Tumors Standard Treatment Surgical removal of the tumor, radiation, bromocriptine or combinations of these treatments. Bromocriptine has been of considerable benefit in reducing symptoms. A new drug, CV205-502, has been successful in patients who have failed to respond to bromocriptine. Investigational • Heavy-particle radiation.